(19)

(11)

EP 4 798 707 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883419.4 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C12N 9/12(2006.01) C12N 15/113(2010.01) A61K 48/00(2006.01) G01N 33/573(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/113; A61K 40/15; C12N 5/0646; C12N 2510/00; C12N 15/90; C12N 2310/20; C12N 9/1276; A61K 40/33; A61K 40/11; A61K 40/4202 (86) International application number: PCT/US2024/053018 (87) International publication number: WO 2025/090906 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 25.10.2023 US 202363593035 P (71) Applicant: Baylor College of Medicine Houston, TX 77030 (US)	(72) Inventors: MAMONKIN, Maksim Houston, Texas 77030 (US) TSAI, Chiou-Tsun Houston, Texas 77030 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)