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(11)

EP 4 798 708 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883409.5 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C12N 9/88(2006.01) A61P 35/00(2006.01) C12N 15/85(2006.01) A61K 38/51(2006.01) C12N 15/52(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12N 9/88; C12Y 401/02027; C12N 15/52; A61K 45/06; A61K 38/00 (86) International application number: PCT/US2024/052997 (87) International publication number: WO 2025/090890 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 25.10.2023 US 202363592984 P (71) Applicant: Board of Regents, The University of Texas System Austin, TX 78701 (US)	(72) Inventors: STONE, Everett Austin, Texas 78731 (US) RODNICK-SMITH, Max Austin, Texas 78751 (US) AL-KHALEDY, Ranya Austin, Texas 78705 (US) GEORGIOU, George Austin, Texas 78731 (US) (74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB  Siebertstraße 3 81675 München 81675 München (DE)