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EP 4 798 709 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883433.5 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C12N 11/02(2006.01) C12N 5/10(2006.01) B82Y 5/00(2011.01) C12N 15/113(2010.01) C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): C12N 11/02; C12N 5/0062; C12N 5/0075; C12N 9/222; C07K 7/08; C12N 15/11; C12N 2310/20 (86) International application number: PCT/US2024/053051 (87) International publication number: WO 2025/090926 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363593464 P (71) Applicant: The Penn State Research Foundation University Park, PA 16802 (US)	(72) Inventors: MEDINA, Scott H. State College, Pennsylvania 16803 (US) MILLER, Michael A. State College, Pennsylvania 16802 (US) (74) Representative: Beck Greener LLP  Fulwood House 12 Fulwood Place London WC1V 6HR London WC1V 6HR (GB)