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(11)

EP 4 798 713 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24802365.7 (22) Date of filing: 22.10.2024

(51) International Patent Classification (IPC):  C12N 15/113(2010.01) A61P 25/28(2006.01) C07K 14/47(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/1138; C12N 2310/14; C07K 14/47; C12N 2310/20; A61P 25/28 (86) International application number: PCT/US2024/052306 (87) International publication number: WO 2025/090427 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592271 P (71) Applicant: University of Rochester Rochester, NY 14642 (US)	(72) Inventors: GOLDMAN, Steven New York 14580 (US) NEDERGAARD, Maiken Rochester, New York 14642 (US) LONG, Carter Rochester, New York 14642 (US) (74) Representative: Brand Murray Fuller LLP  111 Wardour Street London W1F 0UH London W1F 0UH (GB)