(19)
(11) EP 4 798 719 A1

(12)

(43) Date of publication:
02.09.2026 Bulletin 2026/36

(21) Application number: 24886668.3

(22) Date of filing: 28.10.2024
(51) International Patent Classification (IPC): 
C12N 15/113(2010.01)
A61K 31/713(2006.01)
C12N 9/64(2006.01)
A61K 31/7105(2006.01)
A61P 3/06(2006.01)
(52) Cooperative Patent Classification (CPC):
C12N 9/64; A61P 3/06; C12N 15/1137; C12N 2310/321; C12N 2310/322; C12N 2310/351; C12N 2310/3231; C12N 2310/344
 
C-Sets:
  1. C12N 2310/321, C12N 2310/3521;
  2. C12N 2310/322, C12N 2310/3533;

(86) International application number:
PCT/US2024/053283
(87) International publication number:
WO 2025/096355 (08.05.2025 Gazette 2025/19)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 29.10.2023 US 202363546215 P
29.10.2023 US 202363546216 P
29.10.2023 US 202363546217 P

(71) Applicant: Corsera Health, Inc.
Boston, MA 02110 (US)

(72) Inventors:
  • KOTELIANSKI, Victor
    Newton, Massachusetts 02459 (US)
  • KAPETANOVIC, Edi
    Chicago, Illinois 60611 (US)
  • DUEY, Marc
    Chester Springs, Pennsylvania 19425 (US)
  • GANKIN, Yuriy
    Newton, Massachusetts 02459 (US)
  • HULTSCH, Kathrin
    95326 Kulmbach (DE)
  • GEICK, Anke
    95326 Kulmbach (DE)
  • HADWIGER, Philipp
    95326 Kulmbach (DE)

(74) Representative: J A Kemp LLP 
80 Turnmill Street
London EC1M 5QU
London EC1M 5QU (GB)

   


(54) IMPROVED SIRNA FOR SILENCING EXPRESSION OF PCSK9 AND USES THEREOF