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(11)

EP 4 798 721 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883311.3 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  C12N 15/62(2006.01) C12N 9/22(2006.01) A61K 39/00(2006.01) C12N 15/86(2006.01) A61K 35/17(2025.01) C12N 15/113(2010.01) (52) Cooperative Patent Classification (CPC): C12N 9/22; C12N 15/86; C12N 15/11; C12N 2310/20; A61K 38/00; C07K 2319/95; C12N 9/14; C07K 2319/60 (86) International application number: PCT/US2024/052766 (87) International publication number: WO 2025/090736 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363593894 P (71) Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute Seattle, WA 98101 (US)	(72) Inventors: JAMES, Richard G. Seattle, Washington 98101 (US) RAWLINGS, David J. Seattle, Washington 98101 (US) (74) Representative: Plougmann Vingtoft a/s  Strandvejen 70 2900 Hellerup 2900 Hellerup (DK)