(19)

(11)

EP 4 798 724 A1

(12)

(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24789808.3 (22) Date of filing: 09.10.2024

(51) International Patent Classification (IPC):  C12N 15/86(2006.01) C12N 5/00(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/86; C12N 2750/14143; C12N 2750/14151; C12N 5/0018; C12N 2501/727; C12N 2501/405; C12N 2501/999; C12N 2501/065 (86) International application number: PCT/EP2024/078437 (87) International publication number: WO 2025/087695 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 23.10.2023 US 202363592330 P (71) Applicant: Ascend Advanced Therapies Ltd Cheshire WA14 2DT (GB)	(72) Inventors: REID, Christopher Andrew  (GB) MANDEGAR, Mohammad Ali  (GB) GRAFTON, Francis Nadine  (GB) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)