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EP 4 798 731 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883431.9 (22) Date of filing: 25.10.2024

(51) International Patent Classification (IPC):  C12P 19/34(2006.01) C12Q 1/6865(2018.01) C12N 9/12(2006.01) C12Q 1/6855(2018.01) C12N 15/10(2006.01) (52) Cooperative Patent Classification (CPC): C12N 15/10; C12P 19/34; C12N 9/1247 (86) International application number: PCT/US2024/053044 (87) International publication number: WO 2025/090922 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.10.2023 US 202363593687 P (71) Applicant: University of Massachusetts Westborough, MA 01581 (US)	(72) Inventors: MARTIN, Craig Amherst, Massachusetts 01002 (US) MALA, Purnima Amherst, Massachusetts 01002 (US) MALAGODAPATHIRANAGE, Kithmie, Harshana Boxborough, Massachusetts 01719 (US) BANERJEE, Ruptanu Sunderland, Massachusetts 01375 (US) (74) Representative: Henderson, Helen Lee  Withers & Rogers LLP 2 London Bridge London SE1 9RA London SE1 9RA (GB)