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(11)

EP 4 798 963 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24883317.0 (22) Date of filing: 24.10.2024

(51) International Patent Classification (IPC):  G01N 27/62(2021.01) G01N 1/40(2006.01) A61N 1/36(2006.01) G01N 33/00(2006.01) (52) Cooperative Patent Classification (CPC): G01N 33/0034 (86) International application number: PCT/US2024/052789 (87) International publication number: WO 2025/090747 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 24.10.2023 US 202363545388 P (71) Applicant: Virginia Commonwealth University Richmond, VA 23298 (US)	(72) Inventors: COSTANZO, Richard, M. Richmond, VA 23298 (US) HECK, Gerard, L. Richmond, VA 23298 (US) COELHO, Daniel, H. Richmond, VA 23298 (US) (74) Representative: Plasseraud IP  104 Rue de Richelieu CS92104 75080 Paris Cedex 02 75080 Paris Cedex 02 (FR)