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EP 4 798 967 A1

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(43) Date of publication: 02.09.2026 Bulletin 2026/36 (21) Application number: 24881912.0 (22) Date of filing: 27.10.2024

(51) International Patent Classification (IPC):  G01N 33/543(2006.01) G01N 33/68(2006.01) G01N 33/53(2006.01) A61K 39/395(2006.01) G01N 21/64(2006.01) G01N 33/564(2006.01) G01N 33/574(2006.01) G01N 21/84(2006.01) A61K 47/68(2017.01) (52) Cooperative Patent Classification (CPC): G01N 33/564; A61K 39/39566; C07K 16/241; C07K 2317/76; C07K 2317/92; G01N 33/54388; G01N 33/9493 (86) International application number: PCT/IL2024/051037 (87) International publication number: WO 2025/088618 (01.05.2025 Gazette 2025/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 26.10.2023 US 202363545765 P 02.06.2024 US 202463655006 P (71) Applicants: B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University 8410501 Beer Sheva (IL) Rambam Med-Tech Ltd. 3109601 Haifa (IL)

(72) Inventors: KOKOJKA, Frans Be er Sheva (IL) MARKS, Robert 8496500 Omer (IL) PRESSMAN, Sigal 3702133 Pardes Hanna (IL) CHOWERS, Yehuda 6495805 Tel Aviv (IL) (74) Representative: Boult Wade Tennant LLP  Salisbury Square House 8 Salisbury Square London EC4Y 8AP London EC4Y 8AP (GB)