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(11)

EP 4 815 810 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898655.6 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61B 3/14(2006.01) G06N 3/08(2023.01) G06V 10/82(2022.01) A61B 3/12(2006.01) G06V 40/19(2022.01) (52) Cooperative Patent Classification (CPC): G06V 10/82; A61B 3/12; G06N 3/08; A61B 3/14; G06N 20/00; G06N 20/20; G06N 5/01; G06N 3/09; G06V 2201/03; G06V 10/764; G06V 40/193; G06V 40/197 (86) International application number: PCT/US2024/057512 (87) International publication number: WO 2025/117574 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605148 P (71) Applicants: Memorial Sloan Kettering Cancer Center New York, NY 10065 (US) Memorial Hospital for Cancer and Allied Diseases New York, NY 10065 (US) Sloan-kettering Institute For Cancer Research New York, NY 10065 (US)

(72) Inventors: CRUZ-ABRAMS, Owen New York, New York 10065 (US) ABRAMSON, David New York, New York 10065 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)