(19)

(11)

EP 4 815 815 A2

(12)

(88) Date of publication A3: 17.07.2025 (43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817274.4 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  A61B 5/00(2006.01) A61B 8/00(2006.01) (52) Cooperative Patent Classification (CPC): A61B 5/0066; A61B 5/0075; A61B 5/6844; A61B 2562/043; A61B 2560/0431; A61B 2560/0418; A61B 5/7267; A61B 8/4416; A61B 5/6843; A61B 8/085; A61B 8/0825; A61B 8/5223 (86) International application number: PCT/EP2024/083992 (87) International publication number: WO 2025/114479 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 NL 2036383 (71) Applicant: Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis 1066 CX Amsterdam (NL)	(72) Inventors: DASHT BOZORG, Behdad 1066 CX Amsterdam (NL) RUERS, Theodoor Jacques Marie 1066 CX Amsterdam (NL) STERENBORG, Henricus Josephus Cornelus Maria 1066 CX Amsterdam (NL) GELDOF, Freija 1066 CX Amsterdam (NL) (74) Representative: Nederlandsch Octrooibureau  P.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)