(19)

(11)

EP 4 815 912 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817318.9 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 47/26(2006.01) A61K 31/585(2006.01) A61K 47/38(2006.01) (52) Cooperative Patent Classification (CPC): A61K 47/38; A61K 31/585; A61K 47/26; A61K 9/0048 (86) International application number: PCT/EP2024/084152 (87) International publication number: WO 2025/114562 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 EP 23307102 (71) Applicants: Institut National de la Santé et de la Recherche Médicale 75013 Paris (FR) Université Paris Cité 75006 Paris (FR) SORBONNE UNIVERSITE 75006 Paris (FR) Assistance Publique - Hôpitaux de Paris 75012 Paris (FR)

(72) Inventors: BEHAR, Francine 75006 PARIS (FR) ZHAO, Min 75006 PARIS (FR) MEJLACHOWICZ, Dan 75006 PARIS (FR) (74) Representative: Plasseraud IP  104 Rue de Richelieu CS92104 75080 Paris Cedex 02 75080 Paris Cedex 02 (FR)