(19)

(11)

EP 4 815 914 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24827593.5 (22) Date of filing: 02.12.2024

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 9/1272(2025.01) A61K 9/1271(2025.01) A61K 9/51(2006.01) (52) Cooperative Patent Classification (CPC): A61K 9/5123; A61K 9/0019; A61K 9/5192 (86) International application number: PCT/US2024/058122 (87) International publication number: WO 2025/117969 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605295 P (71) Applicant: Orna Therapeutics, Inc. Watertown, MA 02472 (US)	(72) Inventors: JOSHI, Ujjwal Watertown, MA 02472 (US) HORHOTA, Allen, T. Watertown, MA 02472 (US) (74) Representative: Goodwin Procter (UK) LLP  Sancroft, 10-15 Newgate Street EC1A 7AZ / London EC1A 7AZ / London (GB)