(19)

(11)

EP 4 815 920 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898828.9 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 9/08(2006.01) A61B 17/12(2006.01) A61K 31/20(2006.01) A61L 24/02(2006.01) A61K 31/133(2006.01) A61K 31/70(2006.01) (52) Cooperative Patent Classification (CPC): A61L 24/02; A61B 17/12109; A61B 17/12186; A61B 2017/1205; A61L 24/0015; A61L 2300/416; A61L 2300/252; A61L 2300/258; A61L 2300/44; A61L 2300/442; A61K 31/14; A61K 31/201; A61K 31/7004; A61K 31/167; A61K 31/704; A61K 33/243   C-Sets: A61K 31/704, A61K 2300/00; A61K 33/243, A61K 2300/00; A61K 31/201, A61K 2300/00; A61K 31/14, A61K 2300/00; A61K 31/7004, A61K 2300/00; A61K 31/167, A61K 2300/00; (86) International application number: PCT/US2024/057897 (87) International publication number: WO 2025/117852 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363602949 P (71) Applicant: Mayo Foundation for Medical Education and Research Rochester, Minnesota 55905 (US)	(72) Inventor: OKLU, Rahmi Chandler, Arizona 85249 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham, West Midlands B16 8QQ Birmingham, West Midlands B16 8QQ (GB)