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EP 4 815 923 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898751.3 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 9/16(2006.01) A61K 47/69(2017.01) A61P 25/28(2006.01) A61K 9/1275(2025.01) (52) Cooperative Patent Classification (CPC): A61K 9/1275; A61P 25/28 (86) International application number: PCT/US2024/057721 (87) International publication number: WO 2025/117721 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363603090 P (71) Applicant: Massachusetts Institute of Technology Cambridge, MA 02139-4301 (US)	(72) Inventors: TSAI, Li-huei Cambridge, MA 02138 (US) PINALS, Rebecca Boston, MA 02114 (US) LOZANO CRUZ, Claudia, Fernanda Boston, Massachusetts 02114 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)