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EP 4 815 928 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898808.1 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 9/51(2006.01) A61K 48/00(2006.01) A61P 35/00(2006.01) A61K 39/00(2006.01) A61P 31/00(2006.01) A61P 25/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/00; A61P 35/00; A61P 25/00; C12N 15/88; A61K 2039/55555; A61K 39/12; C12N 2760/16134; A61K 2039/53; A61K 2039/575; A61K 2039/54; A61K 2039/545; A61P 31/16; A61K 9/5123 (86) International application number: PCT/US2024/057850 (87) International publication number: WO 2025/117816 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605185 P 01.12.2023 US 202363605386 P 01.12.2023 US 202363605392 P 05.01.2024 US 202463618062 P (71) Applicant: Recode Therapeutics, Inc. Menlo Park, CA 94025 (US)

(72) Inventors: KALIYAPERUMAL, Arunan Menlo Park, CA 94025 (US) CHEN, Min Menlo Park, CA 94025 (US) ISHIMARU, Daniella Menlo Park, CA 94025 (US) CEFALU, Joseph S. Menlo Park, CA 94025 (US) HENNIG, Mirko Menlo Park, CA 94025 (US) MOHAPATRA, Sakya Sing Menlo Park, CA 94025 (US) WANG, Jialu Menlo Park, CA 94025 (US) SRINIVASAN, Karpagam Menlo Park, CA 94025 (US) (74) Representative: Hoffmann Eitle  Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München 81925 München (DE)