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(11)

EP 4 815 930 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24816770.2 (22) Date of filing: 02.12.2024

(51) International Patent Classification (IPC):  A61K 31/122(2006.01) A61P 25/08(2006.01) A61K 31/47(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/47; A61K 31/122; A61P 25/08   C-Sets: A61K 31/47, A61K 2300/00; A61K 31/122, A61K 2300/00; (86) International application number: PCT/EP2024/084345 (87) International publication number: WO 2025/114605 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 EP 23213736 (71) Applicant: Katholieke Universiteit Leuven 3000 Leuven (BE)	(72) Inventors: CAMMUE, Bruno 3000 Leuven (BE) DE WITTE, Peter 3000 Leuven (BE) LAGAE, Lieven 3000 Leuven (BE) NY, Annelii 3000 Leuven (BE) THEVISSEN, Karin 3000 Leuven (BE) (74) Representative: Arnold & Siedsma  Bezuidenhoutseweg 57 2594 AC The Hague 2594 AC The Hague (NL)