(19)

(11)

EP 4 815 935 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898576.4 (22) Date of filing: 25.11.2024

(51) International Patent Classification (IPC):  A61K 31/395(2006.01) A61K 31/18(2006.01) A61K 31/47(2006.01) A61K 31/33(2006.01) (52) Cooperative Patent Classification (CPC): A61K 45/06; A61K 31/519; A61K 31/4409   C-Sets: A61K 31/519, A61K 2300/00; A61K 31/4409, A61K 2300/00; (86) International application number: PCT/US2024/057259 (87) International publication number: WO 2025/117429 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604227 P (71) Applicant: The Children's Medical Center Corporation Boston, MA 02115 (US)	(72) Inventors: ITALIANO, Joseph E. Chestnut Hill, Massachusetts 02457 (US) BECKER, Isabelle C. Jamaica Plain, Massachusetts 02130 (US) (74) Representative: Purdylucey Intellectual Property  23 Ely Place Dublin 2 D02 N285 Dublin 2 D02 N285 (IE)