(19)
(11) EP 4 815 943 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24901401.0

(22) Date of filing: 03.12.2024
(51) International Patent Classification (IPC): 
A61K 31/395(2006.01)
C07D 403/04(2006.01)
 C07D 401/14(2006.01)
A61K 31/33(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 409/14; C07D 421/14; C07D 491/056; C07D 495/04; C07D 497/04; A61K 31/407
(86) International application number:
PCT/US2024/058269
(87) International publication number:
WO 2025/122501 (12.06.2025 Gazette 2025/24)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 03.12.2023 US 202363605555 P

(71) Applicant: Mayo Foundation for Medical Education and Research
Rochester, MN 55905-0001 (US)

(72) Inventors:
  • TUECKMANTEL, Werner
    Fitchburg, WI 53713 (US)
  • KOZIKOWSKI, Alan
    Wallace, MI 49893 (US)
  • BILLADEAU, Daniel Denis
    Rochester, Minnesota 55901 (US)

(74) Representative: Studio Torta S.p.A. 
Via Viotti, 9
10121 Torino
10121 Torino (IT)

   


(54) BENZOTHIOPHENE-3-YL- AND BENZOSELENOPHENE-3-YL (BICLYCLIC HETEROARYL) MALEMIDES AS GSK-3 INHIBITORS