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(11)

EP 4 815 946 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898743.0 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 31/4245(2006.01) A61P 31/04(2006.01) A61K 31/37(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/4245; A61K 31/37; A61P 31/04 (86) International application number: PCT/US2024/057701 (87) International publication number: WO 2025/117707 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605156 P (71) Applicant: The Children's Medical Center Corporation Boston, MA 02115 (US)	(72) Inventors: SCHAEFERS, Matthew M. Boston, Massachusetts 02115 (US) PRIEBE, Gregory P. Boston, Massachusetts 02115 (US) (74) Representative: Simmons & Simmons LLP (Munich)  Lehel Carré Gewürzmühlstraße 11 80538 Munich 80538 Munich (DE)