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EP 4 815 958 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898819.8 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 31/5415(2006.01) A61P 25/28(2006.01) A61P 9/10(2006.01) A61P 13/12(2006.01) A61P 3/10(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/5415; A61P 3/10; A61P 9/10; A61P 13/12; A61P 25/28 (86) International application number: PCT/US2024/057882 (87) International publication number: WO 2025/117839 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604688 P (71) Applicant: The Board of Trustees of the Leland Stanford Junior University Stanford, CA 94305-2038 (US)	(72) Inventors: POKHREL, Suman Redwood City, California 94063 (US) WAKATSUKI, Soichi Redwood City, California 94063 (US) MOCHLY-ROSEN, Daria Menlo Park, California 94025 (US) (74) Representative: Handley, Matthew Edward et al Venner Shipley LLP St James's 79 Oxford Street Manchester M1 6EG Manchester M1 6EG (GB)