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EP 4 815 959 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898609.3 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61K 31/55(2006.01) A61K 36/24(2006.01) A61P 25/32(2006.01) A61P 25/36(2006.01) A61K 31/403(2006.01) C07D 487/00(2006.01) A61P 25/34(2006.01) (52) Cooperative Patent Classification (CPC): A61P 25/32; A61P 25/34; A61P 25/36; C07D 471/22 (86) International application number: PCT/US2024/057374 (87) International publication number: WO 2025/117491 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605223 P 14.04.2024 US 202463633821 P 28.04.2024 US 202463639691 P 01.05.2024 US 202463640885 P 15.05.2024 US 202463647743 P (71) Applicant: Kuleon LLC Seattle, WA 98107 (US)

(72) Inventors: FOREST, Jeremy Seattle, Washington 98107 (US) GILLES, David Seattle, Washington 98107 (US) (74) Representative: Schlich  9 St Catherine's Road Littlehampton West Sussex BN17 5HS West Sussex BN17 5HS (GB)