(19)

(11)

EP 4 815 960 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898656.4 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61K 31/592(2006.01) A61K 31/4184(2006.01) A61K 31/59(2006.01) (52) Cooperative Patent Classification (CPC): C07C 401/00; A61K 45/06; A61K 31/22 (86) International application number: PCT/US2024/057513 (87) International publication number: WO 2025/117575 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605130 P (71) Applicant: The Regents of the University of Colorado, a body corporate Denver, CO 80203 (US)	(72) Inventors: LAMBERT, James Denver, Colorado 80203 (US) NORDEEN, Steven Denver, Colorado 80203 (US) (74) Representative: Murgitroyd & Company  165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)