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EP 4 815 965 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898789.3 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 31/7125(2006.01) A61K 31/712(2006.01) A61K 39/395(2006.01) A61P 35/00(2006.01) C12N 15/113(2010.01) A61K 31/7115(2006.01) A61K 31/713(2006.01) A61K 47/54(2017.01) C07K 16/28(2006.01) (52) Cooperative Patent Classification (CPC): C07K 16/2818; C07K 2317/76; A61K 39/395; A61K 31/713; C12N 15/113; C12N 2310/14; C12N 2310/315; C12N 2310/321; C12N 2310/3341; C12N 2310/3515; C12N 2310/312; C12N 2310/335; C12N 2310/322   C-Sets: A61K 39/395, A61K 2300/00; A61K 31/713, A61K 2300/00; C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2024/057805 (87) International publication number: WO 2025/117786 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603276 P (71) Applicant: Phio Pharmaceuticals Corp. King of Prussia, PA 19406 (US)	(72) Inventors: MAXWELL, Melissa Clinton, MA 01510 (US) CARDIA, James Franklin, MA 02038 (US) FRICKER, Simon North Grafton, MA 01536 (US) CUIFFO, Benjamin Natick, MA 01760 (US) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)