(19)

(11)

EP 4 815 971 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898697.8 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 36/539(2006.01) A61K 36/725(2006.01) A61K 36/484(2006.01) A61K 45/06(2006.01) A61K 36/65(2006.01) A61K 31/4412(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61K 36/484; A61K 36/65; A61P 35/00; A61K 36/539; A61K 36/725; A61K 45/06; A61K 31/44   C-Sets: A61K 31/44, A61K 2300/00; A61K 36/539, A61K 2300/00; A61K 36/484, A61K 2300/00; A61K 36/65, A61K 2300/00; A61K 36/725, A61K 2300/00; (86) International application number: PCT/US2024/057607 (87) International publication number: WO 2025/117638 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605328 P (71) Applicant: Yale University New Haven, CT 06510 (US)	(72) Inventor: CHENG, YungChi New Haven, Connecticut 06519 (US) (74) Representative: Grünecker Patent- und Rechtsanwälte PartG mbB  Leopoldstraße 4 80802 München 80802 München (DE)