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EP 4 815 972 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24827513.3 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61K 38/00(2006.01) C07K 7/08(2006.01) A61K 51/08(2006.01) A61P 35/00(2006.01) C07K 14/47(2006.01) (52) Cooperative Patent Classification (CPC): A61K 51/088; C07K 7/08; A61P 35/00; A61K 38/00; C07K 14/705; C07K 7/56 (86) International application number: PCT/US2024/057532 (87) International publication number: WO 2025/117586 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363603005 P (71) Applicant: Mariana Oncology Inc. Watertown, Massachusetts 02472 (US)

(72) Inventors: HUANG, Chunhui Arlington, Massachusetts 02474 (US) METCALF, Chester A. Needham, Massachusetts 02492 (US) BRUTON, Thomas C. Newmarket, New Hampshire 03857 (US) MA, Zhong Bedford, Massachusetts 01730 (US) WU, Lihua Belmont, Massachusetts 02478 (US) COSTANTE, Roberto 00071 Pomezia (RM) (IT) BRANCA, Danila 00071 Pomezia (RM) (IT) ROSOLIA, Federica 00071 Pomezia (RM) (IT) RICARDO, Alonso Winchester, Massachusetts 01890 (US) (74) Representative: Meyer Mojzes, Melinda  Novartis Pharma AG Patent Department Lichtstrasse 35 4056 Basel 4056 Basel (CH)