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EP 4 815 973 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24816956.7 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  A61K 38/17(2006.01) A61P 1/18(2006.01) A61K 31/00(2006.01) A61K 31/704(2006.01) A61K 33/243(2019.01) A61K 31/675(2006.01) A61P 35/00(2006.01) A61P 7/06(2006.01) A61K 31/513(2006.01) A61K 31/7048(2006.01) G01N 33/50(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/17; A61P 35/00; A61P 7/06; A61P 1/18; A61K 31/704; A61K 31/7048; A61K 31/513; A61K 31/675; A61K 33/243; G01N 2800/52; C12Q 1/6886; C12Q 2600/158; C12Q 2600/118; G01N 33/57595   C-Sets: A61K 33/243, A61K 2300/00; A61K 31/704, A61K 2300/00; A61K 31/7048, A61K 2300/00; A61K 31/513, A61K 2300/00; A61K 31/675, A61K 2300/00; (86) International application number: PCT/EP2024/084049 (87) International publication number: WO 2025/114512 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 EP 23307082 (71) Applicants: Centre National de la Recherche Scientifique 75016 Paris (FR) Université Toulouse III - Paul Sabatier 31400 Toulouse (FR) Institut National de la Santé et de la Recherche Médicale 75013 Paris (FR) UNIVERSITE CLAUDE BERNARD LYON 1 69100 Villeurbanne (FR) CENTRE LEON BERARD 69008 Lyon (FR)

(72) Inventors: LEBARON, Simon 31062 TOULOUSE CEDEX 9 (FR) TAGNERES, Sophie 31062 TOULOUSE (FR) GLEIZES, Pierre-Emmanuel 31062 TOULOUSE CEDEX 9 (FR) PLISSON-CHASTANG, Célia 31062 TOULOUSE CEDEX 9 (FR) MARCEL, Virginie 69008 LYON (FR) (74) Representative: Plasseraud IP  104 Rue de Richelieu CS92104 75080 Paris Cedex 02 75080 Paris Cedex 02 (FR)