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EP 4 815 984 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24828223.8 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) A61K 31/47(2006.01) C07K 16/28(2006.01) A61K 31/00(2006.01) A61K 45/06(2006.01) (52) Cooperative Patent Classification (CPC): A61K 2039/505; A61K 39/3955; A61K 2039/545; C07K 2317/76; C07K 16/2839; A61K 45/06; A61K 31/5377; A61K 2300/00 (86) International application number: PCT/US2024/057400 (87) International publication number: WO 2025/117506 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363604090 P (71) Applicant: Gilead Sciences Inc. Foster City, California 94404 (US)

(72) Inventors: CLARKE, Astrid S. San Marcos, California 92078 (US) KUO, Dahtsing Foster City, California 94404 (US) LOPEZ, David A. Foster City, California 94404 (US) ROEDDER, Silke Menlo Park, California 94025 (US) YI, Tangsheng Foster City, California 94404 (US) ZHOU, Jin Foster City, California 94404 (US) GENOVESE, Mark C. Sunnyvale, California 94087 (US) (74) Representative: Schnappauf, Georg  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)