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EP 4 815 985 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898346.2 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) G01N 33/68(2006.01) C07K 16/40(2006.01) A61P 27/02(2006.01) (52) Cooperative Patent Classification (CPC): A61P 27/02; C07K 16/40; C07K 2317/76; A61K 2039/505; A61K 2039/54; G01N 33/6893; G01N 2800/52; G01N 2800/50; G01N 2800/16 (86) International application number: PCT/SG2024/050757 (87) International publication number: WO 2025/116819 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 SG 10202303390S (71) Applicant: Agency for Science, Technology and Research Singapore 138632 (SG)	(72) Inventors: ANG, Koon Hwee Singapore 138673 (SG) THURA, Min Singapore 138673 (SG) SU, Xinyi Singapore 138673 (SG) ZENG, Qi Singapore 138673 (SG) (74) Representative: Potter Clarkson  Chapel Quarter Mount Street Nottingham NG1 6HQ Nottingham NG1 6HQ (GB)