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(11)

EP 4 815 989 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898827.1 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 40/31(2025.01) C07K 14/47(2006.01) A61K 38/39(2006.01) A61K 40/11(2025.01) C07K 19/00(2006.01) A61P 35/00(2006.01) C07K 16/30(2006.01) A61K 39/395(2006.01) A61K 35/17(2025.01) (52) Cooperative Patent Classification (CPC): A61K 40/11; A61K 40/31; A61P 35/00; A61K 40/4255; A61K 40/33; A61K 40/4244; A61K 2239/54; A61K 40/4211; A61K 2239/59; A61K 31/519; A61K 31/16   C-Sets: A61K 31/519, A61K 2300/00; A61K 31/16, A61K 2300/00; (86) International application number: PCT/US2024/057896 (87) International publication number: WO 2025/117851 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 US 202363604730 P (71) Applicant: The General Hospital Corporation Boston, MA 02114 (US)	(72) Inventors: MAUS, Marcela, V. Lexington, MA 02421 (US) BERGER, Trisha, R. Worcester, MA 01606 (US) (74) Representative: Maiwald GmbH  Elisenhof Elisenstraße 3 80335 München 80335 München (DE)