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(11)

EP 4 815 990 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898733.1 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 45/00(2006.01) A61P 35/00(2006.01) C12Q 1/6886(2018.01) A61K 45/06(2006.01) C12Q 1/6883(2018.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C12Q 1/6886; C12Q 2600/156; C12Q 2600/106; A61K 31/427; A61K 31/495; C12Y 305/03006; C12Y 305/03001; A61K 38/50   C-Sets: A61K 31/495, A61K 2300/00; (86) International application number: PCT/US2024/057684 (87) International publication number: WO 2025/117694 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363604084 P (71) Applicant: Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)	(72) Inventors: BREUNIG, Joshua Beverly Hills, California 90210 (US) RINCON FERNANDEZ PACHECO, David Los Angeles, California 90064 (US) (74) Representative: Hutter, Anton  Venner Shipley LLP 5 Stirling House Stirling Road The Surrey Research Park Guildford GU2 7RF Guildford GU2 7RF (GB)