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(11)

EP 4 815 998 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898649.9 (22) Date of filing: 26.11.2024

(51) International Patent Classification (IPC):  A61K 47/68(2017.01) A61K 39/395(2006.01) C07K 16/30(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; C07K 16/3092; A61K 47/6849; A61K 47/6851; A61K 47/6809 (86) International application number: PCT/US2024/057491 (87) International publication number: WO 2025/117564 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 27.11.2023 US 202363603059 P 30.11.2023 US 202363604528 P (71) Applicant: Dana-Farber Cancer Institute, Inc. Boston, Massachusetts 02215 (US)	(72) Inventor: KUFE, Donald Boston, Massachusetts 02215 (US) (74) Representative: Elkington and Fife LLP  Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)