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EP 4 816 000 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898832.1 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  A61K 48/00(2006.01) A61P 7/04(2006.01) C12N 15/113(2010.01) A61K 31/7088(2006.01) A61K 9/127(2025.01) C07K 14/755(2006.01) C12N 9/22(2006.01) (52) Cooperative Patent Classification (CPC): A61P 7/04; C07K 14/755; C12N 9/22; C12N 15/113; A61K 31/711; C12N 15/85; A61K 48/005; C12N 15/88; A61K 38/00; A61K 9/1271; A61K 9/5146; A61K 9/0019; C12N 2310/20; C12N 2310/315; C12N 2310/321; C12N 2310/322; C12N 2320/33   C-Sets: C12N 2310/321, C12N 2310/3521; C12N 2310/322, C12N 2310/3533; (86) International application number: PCT/US2024/057905 (87) International publication number: WO 2025/117858 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 US 202363603511 P 26.07.2024 US 202463676239 P 09.09.2024 US 202463692539 P 06.11.2024 US 202463717090 P (71) Applicant: Metagenomi Therapeutics, Inc. Emeryville, CA 94608 (US)

(72) Inventors: THOMAS, Brian C. Emeryville, California 94608 (US) AFRIKANOVA, Ivka Emeryville, California 94608 (US) BROOKS, Alan Emeryville, California 94608 (US) GAMBOA, Luis Emeryville, California 94608 (US) HO, Samuel Emeryville, California 94608 (US) MEI, Janet Emeryville, California 94608 (US) STANTEN, Kalya Emeryville, California 94608 (US) SZYMANSKI, Paul Emeryville, California 94608 (US) TASSA, Carlos Emeryville, California 94608 (US) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)