(19)

(11)

EP 4 816 005 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817313.0 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  A61K 51/12(2006.01) A61P 35/00(2006.01) A61K 51/04(2006.01) A61K 101/02(2006.01) (52) Cooperative Patent Classification (CPC): A61P 35/00; A61K 51/1234; A61K 51/0491; A61K 9/1075; A61K 9/1271; A61K 51/1227 (86) International application number: PCT/EP2024/084136 (87) International publication number: WO 2025/114552 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 EP 23212935 (71) Applicants: University of Southern Denmark 5230 Odense M (DK) Region Syddanmark 7100 Vejle (DK) Danmarks Tekniske Universitet 2800 Kongens Lyngby (DK)

(72) Inventors: THISGAARD, Helge 5500 Middelfart (DK) HALLE, Bo 5250 Odense SV (DK) NIELSEN, Aaraby 5000 Odense C (DK) INGEMANN JENSEN, Andreas Tue 2800 Kongens Lyngby (DK) STRAATHOF, Natan 2800 Kongens Lyngby (DK) TANG, Qing 2800 Kongens Lyngby (DK) (74) Representative: Høiberg P/S  Adelgade 12 1304 Copenhagen K 1304 Copenhagen K (DK)