(19)
(11) EP 4 816 063 A1

(12)

(43) Date of publication:
07.10.2026 Bulletin 2026/41

(21) Application number: 24821755.6

(22) Date of filing: 29.11.2024
(51) International Patent Classification (IPC): 
A61P 35/00(2006.01)
C07D 233/88(2006.01)
C07D 243/04(2006.01)
A61K 31/55(2006.01)
 C07D 233/44(2006.01)
C07D 239/18(2006.01)
A61K 31/4168(2006.01)
A61K 31/505(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 233/88; C07D 233/44; C07D 239/18; C07D 243/04; A61P 35/00
(86) International application number:
PCT/EP2024/084185
(87) International publication number:
WO 2025/114580 (05.06.2025 Gazette 2025/23)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA
Designated Validation States:
GE KH MA MD TN

(30) Priority: 30.11.2023 EP 23386128

(71) Applicants:
  • National and Kapodistrian University of Athens
    10679 Athens (GR)
  • Universiteit Gent
    9000 Gent (BE)

(72) Inventors:
  • VOUGIOUKALAKIS, Georgios
    15771 Athens (GR)
  • TZOURAS, Nikolaos
    15771 Athens (GR)
  • TONIS, Efstathios
    15771 Athens (GR)
  • ELIOPOULOS, Aristides
    11527 Athens (GR)
  • MINADAKI, Maria
    11527 Athens (GR)
  • NOLAN, Steven
    9000 Gent (BE)

(74) Representative: Dodou, Evdokia 
Katsimpiri 3
15561 Cholargos, Athens
15561 Cholargos, Athens (GR)

   


(54) N-AMINOGUANIDINE DERIVATIVES WITH ANTICANCER ACTIVITY