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EP 4 816 064 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24827808.7 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  A61P 35/00(2006.01) C07K 16/40(2006.01) C07K 14/52(2006.01) (52) Cooperative Patent Classification (CPC): A61K 2039/505; A61P 35/00; C07K 16/40; C07K 2317/24; C07K 2317/33; C07K 2317/92; C07K 2319/33; C07K 2319/00; C07K 14/70575; C12N 9/50 (86) International application number: PCT/CN2024/135694 (87) International publication number: WO 2025/113643 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 WO PCT/CN2023/135902 12.11.2024 WO PCT/CN2024/131641 (71) Applicant: Gilead Sciences Inc. Foster City, California 94404 (US)	(72) Inventors: ZHAI, Qianting Shanghai 200233 (CN) FEI, Mingjian Shanghai 200233 (CN) CAO, Jun Shanghai 200233 (CN) SUN, Runzi Shanghai 200233 (CN) LI, Lixue Shanghai 200233 (CN) ZHU, Hui Shanghai 200233 (CN) (74) Representative: Schnappauf, Georg  ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München 80686 München (DE)