ANALOGS OF QUINOXALINE/QUINOLINE CYTOTOXINS, LINKER- PAYLOADS, PROTEIN-DRUG CONJUGATES, AND USES THEREOF - Patent 4816065

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EP 4 816 065 A1

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(43)	Date of publication:
	07.10.2026 Bulletin 2026/41

(21)	Application number: 24828580.1

(22)	Date of filing: 27.11.2024

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International Patent Classification (IPC):

A61P 35/00^(2006.01)
A61K 31/438^(2006.01)

C07D 519/00^(2006.01)

(52)	Cooperative Patent Classification (CPC):
	C07D 519/00; A61P 35/00

(86)	International application number:
	PCT/US2024/057728

(87)	International publication number:
	WO 2025/117727 (05.06.2025 Gazette 2025/23)

(84)	Designated Contracting States:
	AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR
	Designated Extension States:
	BA
	Designated Validation States:
	GE KH MA MD TN

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Priority:

29.11.2023 US 202363603966 P
28.08.2024 US 202463688088 P

(71)	Applicant: Regeneron Pharmaceuticals, Inc.
	Tarrytown, NY 10591 (US)

(72)	Inventors:
	NITTOLI, Thomas Tarrytown, New York 10591 (US) ANSARI, Nurul Hoda Tarrytown, New York 10591 (US) YU, Po-Cheng Tarrytown, New York 10591 (US)

(74)	Representative: Crow, Martin et al
	Venner Shipley LLP TIDE Bankside 8 Emerson Street London SE1 9DU London SE1 9DU (GB)

(54)	ANALOGS OF QUINOXALINE/QUINOLINE CYTOTOXINS, LINKER- PAYLOADS, PROTEIN-DRUG CONJUGATES, AND USES THEREOF