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EP 4 816 353 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898716.6 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07D 231/06(2006.01) A61K 31/4439(2006.01) C07D 487/04(2006.01) A61K 31/416(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 487/04; C07D 231/56; C07D 401/14 (86) International application number: PCT/US2024/057658 (87) International publication number: WO 2025/117672 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605105 P (71) Applicant: Hotspot Therapeutics, Inc. Boston, Massachusetts 02210 (US)	(72) Inventors: CARSON, Kenneth G. Princeton, New Jersey 08540 (US) BI, Yingzhi Plainsboro, New Jersey 08536 (US) HARRIMAN, Geraldine Cirillo Charlestown, Rhode Island 02813 (US) DILLER, David J. East Windsor, New Jersey 08520 (US) MORADEI, Oscar Miguel Burlington, Massachusetts 01803 (US) (74) Representative: Cooley (UK) LLP  22 Bishopsgate London EC2N 4BQ London EC2N 4BQ (GB)