(19)

(11)

EP 4 816 354 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817602.6 (22) Date of filing: 02.12.2024

(51) International Patent Classification (IPC):  C07D 233/88(2006.01) A61P 31/04(2006.01) A61K 31/4168(2006.01) (52) Cooperative Patent Classification (CPC): C07D 233/88; A61P 31/04 (86) International application number: PCT/EP2024/084347 (87) International publication number: WO 2025/114606 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 30.11.2023 EP 23213479 (71) Applicant: Katholieke Universiteit Leuven 3000 Leuven (BE)	(72) Inventor: STEENACKERS, Hans 3000 Leuven (BE) (74) Representative: Arnold & Siedsma  Bezuidenhoutseweg 57 2594 AC The Hague 2594 AC The Hague (NL)