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EP 4 816 355 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898853.7 (22) Date of filing: 29.11.2024

(51) International Patent Classification (IPC):  C07D 239/88(2006.01) A61K 31/506(2006.01) A61P 1/16(2006.01) C07D 213/02(2006.01) C07D 239/70(2006.01) A61K 31/44(2006.01) A61K 31/517(2006.01) A61P 35/00(2006.01) C07D 239/34(2006.01) (52) Cooperative Patent Classification (CPC): A61P 1/16; A61P 35/00; C07D 239/70; C07D 401/12; C07D 491/107; C07D 403/12; C07D 487/04; C07D 491/113; C07D 405/14; C07D 413/14; C07D 417/14; C07D 401/14; C07D 471/04; C07D 409/14; C07D 239/95; C07D 241/44; C07D 405/12; C07D 519/00; C07D 403/14; C07D 493/10; C07D 409/04; C07D 495/04; C07D 311/22; C07D 215/36; C07D 217/24 (86) International application number: PCT/US2024/057958 (87) International publication number: WO 2025/117886 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605380 P (71) Applicant: Casma Therapeutics, Inc. Boston, Massachusetts 02115 (US)	(72) Inventors: LIN, Jian Boston, MA 02115 (US) SAUNDERS, Jeffrey Owen Boston, MA 02115 (US) GARCIA FORTANET, Jorge Boston, MA 02115 (US) MEREDITH, Erik Lee Boston, MA 02115 (US) MAYNARD, Andrew Thomas Boston, MA 02115 (US) APPLETON, Brent A. Boston, MA 02115 (US) BROADUS, Matthew Ryan Boston, MA 02115 (US) (74) Representative: J A Kemp LLP  80 Turnmill Street London EC1M 5QU London EC1M 5QU (GB)