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(11)

EP 4 816 360 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898531.9 (22) Date of filing: 21.11.2024

(51) International Patent Classification (IPC):  C07D 309/10(2006.01) A61P 35/00(2006.01) A61K 31/7028(2006.01) (52) Cooperative Patent Classification (CPC): A61K 31/7028; A61P 35/00; A61K 45/06; C07K 16/2803; C07K 16/32; A61K 2039/507; A61K 39/39558; C07H 15/04; A61K 31/7056; A61K 47/55; A61K 47/549   C-Sets: A61K 39/39558, A61K 2300/00; A61K 31/7056, A61K 2300/00; (86) International application number: PCT/US2024/056790 (87) International publication number: WO 2025/117308 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363603675 P 12.01.2024 US 202463620199 P 09.10.2024 US 202463705103 P (71) Applicant: The Scripps Research Institute La Jolla, CA 92037 (US)

(72) Inventors: WU, Peng San Diego, CA 92122 (US) WANG, Chao Palm Beach Garden, FL 33418 (US) (74) Representative: Hutter, Anton  Venner Shipley LLP 5 Stirling House Stirling Road The Surrey Research Park Guildford GU2 7RF Guildford GU2 7RF (GB)