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EP 4 816 362 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898351.2 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) C12Q 1/18(2006.01) A61P 31/04(2006.01) C09K 11/06(2006.01) A61K 31/4425(2006.01) A61P 31/10(2006.01) (52) Cooperative Patent Classification (CPC): A61P 31/04; A61P 31/10; C07D 213/38; C09K 11/06; G01N 33/56911; G01N 33/56961; G01N 33/582; C09K 2211/1433; C09K 2211/1466 (86) International application number: PCT/SG2024/050763 (87) International publication number: WO 2025/116824 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 CN 202311600452 (71) Applicants: National University of Singapore Singapore 119077 (SG) Tianjin University Tianjin 300072 (CN)	(72) Inventors: LIU, Bin Singapore 119077 (SG) LIU, Xianglong Singapore 119077 (SG) QI, Guobin Singapore 119077 (SG) (74) Representative: Marks & Clerk LLP  15 Fetter Lane London EC4A 1BW London EC4A 1BW (GB)