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EP 4 816 364 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24828233.7 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07D 401/14(2006.01) A61K 31/506(2006.01) A61P 35/00(2006.01) C07D 403/14(2006.01) A61P 31/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 401/14; C07D 403/14; A61P 35/00; A61P 31/00 (86) International application number: PCT/US2024/057671 (87) International publication number: WO 2025/117682 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605062 P (71) Applicant: Blueprint Medicines Corporation Cambridge, MA 02139 (US)

(72) Inventors: RAMSDEN, Philip D. Cambridge, Massachusetts 02139 (US) BOPPANA, Kiran Hyderabad, 500 076 (IN) LIU, Xiang Cambridge, Massachusetts 02139 (US) DINEEN, Thomas A. Cambridge, Massachusetts 02139 (US) MALINENI, Jagadeesh Hyderabad, 500 076 (IN) NAGASWAMY, Kumaragurubaran Hyderabad, 500 076 (IN) THANGATHIRUPATHY, Srinivasan Hyderabad, 500 076 (IN) TORRES, Luis Cambridge, Massachusetts 02139 (US) (74) Representative: Mathys & Squire  32 London Bridge Street The Shard London SE1 9SG London SE1 9SG (GB)