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EP 4 816 368 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24837228.6 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07D 409/04(2006.01) C07D 413/14(2006.01) C07D 487/10(2006.01) C07D 519/00(2006.01) A61K 31/517(2006.01) A61K 31/5517(2006.01) A61K 31/5386(2006.01) A61K 31/5395(2006.01) C07D 409/14(2006.01) C07D 487/04(2006.01) C07D 489/04(2006.01) A61P 35/00(2006.01) A61K 31/5377(2006.01) A61K 31/519(2006.01) A61K 31/55(2006.01) (52) Cooperative Patent Classification (CPC): C07D 487/04; C07D 519/00; C07D 409/14; C07D 487/10; C07D 413/14; C07D 409/04; C07D 489/04; A61P 35/00 (86) International application number: PCT/US2024/057867 (87) International publication number: WO 2025/117828 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605348 P 07.02.2024 US 202463550896 P 10.06.2024 US 202463658325 P (71) Applicants: Theras, Inc. South San Francisco, CA 94080 (US) Leidos Biomedical Research Inc. Frederick, Maryland 21702-1201 (US) Lawrence Livermore National Security, LLC Livermore, California 94550 (US)

(72) Inventors: ZHANG, Zuhui San Francisco, California 94080 (US) WANG, Bin San Francisco, California 94080 (US) XU, Rui San Francisco, California 94080 (US) WALLACE, Eli San Francisco, California 94080 (US) TURNER, David Michael Frederick, Maryland 21702 (US) MACIAG, Anna Elzbieta Frederick, Maryland 21702 (US) SIMANSHU, Dhirendra Kumar Frederick, Maryland 21702 (US) CHAN, Albert Hay Wah Frederick, Maryland 21702 (US) LIAO, Tao Frederick, Maryland 21702 (US) YANG, Yue Livermore, California 94550 (US) PEI, Jun Livermore, California 94550 (US) LIGHTSTONE, Felice Livermore, California 94550 (US) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)