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EP 4 816 371 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24861322.6 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C07D 471/04(2006.01) A61K 31/506(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 471/04; A61P 35/00 (86) International application number: PCT/CN2024/135245 (87) International publication number: WO 2025/113558 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 WO PCT/CN2023/134994 (71) Applicant: GENENTECH, INC. South San Francisco, CA 94080 (US)

(72) Inventors: ZHONG, Wenge Cambridge, Massachusetts 02142 (US) ZHU, Xiaotian Cambridge, Massachusetts 02142 (US) HU, Zhilong Shanghai 201210 (CN) HE, Hu Shanghai 201210 (CN) ZHANG, Fei Shanghai 201210 (CN) LI, Zheng Jane Beijing 100176 (CN) CHEN, Pengyuan Beijing 100176 (CN) JIANG, Xiawei Beijing 100176 (CN) (74) Representative: HGF  HGF Limited 4th Floor, 1 City Square Leeds LS1 2ES Leeds LS1 2ES (GB)