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(11)

EP 4 816 373 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24817863.4 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C07D 513/14(2006.01) C07D 471/14(2006.01) A61K 31/519(2006.01) C07D 498/14(2006.01) A61P 35/00(2006.01) (52) Cooperative Patent Classification (CPC): C07D 513/14; C07D 471/14; C07D 498/14; A61P 35/00 (86) International application number: PCT/EP2024/083952 (87) International publication number: WO 2025/114459 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 28.11.2023 GB 202318175 11.12.2023 GB 202318866 24.05.2024 GB 202407458 (71) Applicant: Genome Therapeutics Ltd London SE19 3HF (GB)	(72) Inventors: BALASUBRAMANIAN, Shankar Cambridge Lensfield Road Cambridge CB2 1EW (GB) MEO, Paul Cambridge Lensfield Road Cambridge CB2 1EW (GB) (74) Representative: Johnson, Stephen William et al Venner Shipley LLP 406 Cambridge Science Park Milton Road Cambridge CB4 0WW Cambridge CB4 0WW (GB)