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(11)

EP 4 816 380 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24827882.2 (22) Date of filing: 28.11.2024

(51) International Patent Classification (IPC):  C07K 7/06(2006.01) A61K 38/04(2006.01) A61K 38/00(2006.01) C07K 7/08(2006.01) (52) Cooperative Patent Classification (CPC): A61K 38/00; C07K 7/02; C07K 7/06 (86) International application number: PCT/IB2024/062001 (87) International publication number: WO 2025/114944 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 IT 202300025383 (71) Applicant: Universita' Degli Studi di Siena 53100 Siena (IT)	(72) Inventors: FALCIANI, Chiara 53100 Siena (IT) BRACCI, Luisa 53100 Siena (IT) RENCINAI, Alessandro 53048 Sinalunga (IT) BRUNETTI, Jlenia 53031 Casole d Elsa (IT) PINI, Alessandro 53100 Siena (IT) (74) Representative: Zaccaro, Elisabetta et al Notarbartolo & Gervasi S.p.A. Viale Achille Papa, 30 20149 Milano 20149 Milano (IT)