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(11)

EP 4 816 389 A1

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(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24840943.5 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07K 14/565(2006.01) A61K 48/00(2006.01) C07K 7/06(2006.01) A61K 38/17(2006.01) A61P 27/02(2006.01) C07K 14/81(2006.01) (52) Cooperative Patent Classification (CPC): A61P 27/02; C07K 14/565; C07K 14/811; C07K 7/06; C12N 15/85; A61K 38/00 (86) International application number: PCT/US2024/057784 (87) International publication number: WO 2025/117767 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 29.11.2023 US 202363604026 P (71) Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services Bethesda, Maryland 20892-7788 (US)

(72) Inventors: BECERRA, Sofia Patricia Bethesda, Maryland 20892 (US) BERNARDO-COLON, Alexandra Bethesda, Maryland 20892 (US) SWENSON, Rolf E. Rockville, Maryland 20850 (US) BLACKMAN, Burchelle N. Bethesda, Maryland 20814 (US) DEBNATH, Subrata Bethesda, Maryland 20892 (US) RAJU, Natarajan Rockville, Maryland 20850 (US) (74) Representative: Mewburn Ellis LLP  Aurora Building Counterslip Bristol BS1 6BX Bristol BS1 6BX (GB)