(19)

(11)

EP 4 816 392 A1

(12)

(43) Date of publication: 07.10.2026 Bulletin 2026/41 (21) Application number: 24898804.0 (22) Date of filing: 27.11.2024

(51) International Patent Classification (IPC):  C07K 14/82(2006.01) C07K 14/47(2006.01) A61K 35/00(2006.01) C12N 9/64(2006.01) C07K 14/71(2006.01) (52) Cooperative Patent Classification (CPC): C07K 14/71; C12N 9/6424; C12N 9/12; A61P 35/00; C12N 9/50; C07K 2319/00; C12Q 1/6886; C12Q 2600/156 (86) International application number: PCT/US2024/057844 (87) International publication number: WO 2025/117812 (05.06.2025 Gazette 2025/23)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC ME MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA Designated Validation States: GE KH MA MD TN (30) Priority: 01.12.2023 US 202363605179 P (71) Applicant: Foundation Medicine, Inc. Boston, MA 02210 (US)	(72) Inventors: LEE, Jessica, K. Boston, Massachusetts 02210 (US) PASQUINA, Lincoln, W. Boston, Massachusetts 02210 (US) TUKACHINSKY, Hanna Boston, Massachusetts 02210 (US) (74) Representative: CMS Cameron McKenna Nabarro Olswang LLP  Cannon Place 78 Cannon Street London EC4N 6AF London EC4N 6AF (GB)